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"Oral drug delivery brings forth massive advantages that can help overcome these barriers. But with oral routes, there are other challenges as more than 90 per cent of orally administered therapeutic drugs have less than 2 per cent bioavailability and potentially high hepatic and renal toxic side-effects," the release said. A team led by Shyam Lal from the Institute of Nano-Science and Technology (INST), an autonomous institute of the Department of Science and Technology, has developed a smart and intelligent nano-carrier utilising the natural intrinsic Vitamin B12 pathway present in human body that can mitigate stability challenges and drug-associated toxicity.

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The team has disguised the toxic but highly efficient drug of the disease within a biocompatible lipid nano-carrier, shielding it from degradation in the hostile gastric environment, thus overcoming the gastrointestinal enzymatic barriers endured by any foreign synthetic drug molecule. "This minimied its side effects, while the natural intrinsic Vitamin B12 pathway enhanced the oral bioavailability and anti-Leishmanial therapeutic efficacy by more than 90 per cent, as shown in the associated animal studies," the release said. The INST team critically evaluated the efficacy and properties of Vitamin B12 (VB12) coated solid lipid nano-particles and their subsequent potential ramification in evading cytotoxicity and escalating stability.

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