Ira Khan said that she has cyclic depression which comes back in phases. "Every 8-10 months I will have a big crash. It’s partly genetic, partly psychological, and partly social. It took me a while to figure it out. But I have mental health disorders in my family. I also did not make healthy choices and I systematically walked into depression. I had a very big dip in July last year. I had stopped taking my medication and also put on a lot of weight. I developed a mental block against working out."

Ira is Aamir Khan and Reena Dutta's second child. She has an older brother, Junaid Khan. Aamir and Reena parted ways in 2002. Later, Aamir married Kiran Rao and they had a son, Azad. In 2021, Aamir and Kiran announced their separation.

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Meanwhile, Ira Khan has launched Agastu Foundation to aid mental health support. Aamir and Reena are part of the advisory board of the organization.

Ira Khan is quite vocal about her mental health on social media. She recently wrote a note for people feeling suicidal in the capacity of a certified suicide prevention gatekeeper.